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9/26/2014  |   4:30 PM - 6:00 PM   |  

Long term follow up of infants with congenital CMV infection from a high seroprevalence population.

Reliable data on long?term outcomes and disease burden of congenital CMV infection from developing countries is lacking. We describe updated findings on outcomes of congenitally infected infants identified by neonatal screening in a population with high CMV seroprevalence. Eight seven infants with congenital CMV diagnosed at birth (CMV DNA detection in saliva and urine within two weeks of life) were followed from birth to a median age of 54 months (range 45 to 84). During follow-up visits, audiologic evaluation was performed by auditory brainstem evoked response testing in children younger than 3 years of age and conditioned audiometry measurement in those older than 3 years of age. Neuroimaging was performed in all infants at birth. Ophthalmologic assessment was performed at birth and at the latest visit. Among 87 congenitally infected infants, 11(12.6%) were symptomatic at birth. At follow-up, moderate/severe neurological impairment was observed in 73% (8/11) symptomatic infants. Sensorineural hearing loss (SNHL) was observed in 10/87 (11,5%) children (6 symptomatic and 4 asymptomatic at birth). Five children had profound bilateral SNHL and among these, cochlear implantation was performed in 3. All infants with SNHL were identified within one year of age and no progression was detected in any of them. Within the 77 normal hearing infants, none developed SNHL after one year of age. No symptomatic or asymptomatic children showed ophthalmologic findings. The type of maternal CMV infection could be determined in 7 infants with SNHL with or without motor/cognitive deficit; 6 were born to mothers with nonprimary infection and only one was born to a mother with primary infection. Although the disease burden with respect to neurological and audiological impairment is similar to that found in populations from developed countries, ocular findings and late onset (>1year) SNHL seems to be not a problem in congenitally infected infants from developing countries.

Aparecida Yamamoto (Point of Contact,Primary Presenter,Author), yulie@fmrp.usp.br;
n/a

ASHA DISCLOSURE:

Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

Marisa Mussi-Pinhata (Primary Presenter,Author), mmmpinha@fmrp.usp.br;
Marisa M. Mussi-Pinhata, MD, has a broad background in Pediatrics and Clinical Research, with specific training and expertise in neonatology and maternal/infant infections. Since her postdoctoral research fellowship in HIV/AIDS in the US, she has been involved with research with focus on HIV, CMV, and hepatitis. She is a leader of a Clinical Research Site that is part of international research networks in Infectious Diseases. Currently she is a Full Professor of Pediatrics and occupies the function of chief of the Department of Pediatrics of Ribeirão Preto Medical School, University of São Paulo, Brazil. She has authored or co-authored 69 peer-reviewed publications and has received several research supports and awards for research works.

ASHA DISCLOSURE:

Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

Fabiana Rezende Amaral (Author), biarezendeamaral@yahoo.com.br;
Fabiana Rezende Amaral, MD, is a pediatrician who especializes in pediatric infectious diseases. Currently she is a postgraduate student in the Faculty of Medicine at Ribeirão Preto, University of São Paulo.

Fernanda Tomé Sturzbecher (Author), fersiltome@yahoo.com.br;
Fernanda Tomé Sturzbecher M.D, is a pediatrician who especializes in pediatric infectious diseases. Currently she is a postgraduate student in the Faculty of Medicine at Ribeirão Preto, University of São Paulo.

Adriana Carnevale (Author), dricarnevaleneonatologia@gmail.com;
Adriana Carnevale , MD, is a pediatrician who especializes in neonatology. Currently she is a postgraduate student in the Faculty of Medicine at Ribeirão Preto, University of São Paulo.

Cristina Gardony Carvalheiro (Author), cristina.carvalheiro@terra.com.br;
Cristina Gardony Carvalheiro, MD, is currently a pediatrician of the Department of Pediatrics at Faculty of Medicine of Ribeirão Preto- University of São Paulo, Brazil. She has a specific training and expertise in neonatology.

Alessandra Manfredi (Author), alekerli@yahoo.com.br;
Alessandra K. da Silva Manfredi, MSc, is a fonoaudiologist at Department of Ophtalmology and Otorrinolaringology , Faculty of Medicine of Ribeirão Preto- University of São Paulo, Brazil. She completed her Masters Degree and doctoral degree in Pediatric Assessment and Rehabilitation, Psychoacoustics and Diagnostic Audiology (Immittance and Otoacoustic Emissions).

Myriam Lima Isaac (Author), mylis@fmrp.usp.br ;
Myriam de Lima Isaac, MD, is currently a Full Professor of Department of Ophtalmology, Otorrinolaringology, and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto- University of São Paulo, Brazil. She has a specific training and expertise in Pediatric Assessment and Rehabilitation, Psychoacoustics, Implantable Hearing Devices, Diagnostic Audiology (Immittance and Otoacoustic Emissions.

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