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9/26/2014  |   4:30 PM - 6:00 PM   |  

Acceptability of Newborn Cytomegalovirus (CMV) Screening in Women: Findings from the NIDCD CHIMES Study

Acceptability of newborn CMV screening programs by parents is unknown. Our study evaluated whether race, ethnicity or age were associated with participation rates or permission for specimen storage in the NIDCD CMV & Hearing Multicenter Screening (CHIMES) study. Mothers of infants born at seven medical centers were approached after delivery for their consent to screen their infant while in the newborn nursery for congenital CMV infection. As part of the consent process, they were asked for permission to store their infants’ specimens for future research. Between 2007 and 2012, 108,925 women were approached to participate in the newborn CMV screening study. Overall 92.4% agreed to screening, with non-Hispanic black women (91.3%, 95% CI, 91.0% – 91.6%) less likely to participate than non-Hispanic white women (94.4%, 95% CI, 94.1% - 94.6%) and Hispanic white women (97.5%, 95%CI, 97.4% - 97.7%). Women < 25 years of age were more likely to participate than older women. Adjusted for age, non-Hispanic black women were twice as likely to refuse participation (aOR=2.2, 95%CI, 2.1 – 2.4) than non-Hispanic white women, whereas Hispanic white women (aOR=1.9, 95%CI, 1.7 – 2.0) were almost twice as likely to agree to participation as non-Hispanic white women. Among the enrollees, 91% agreed to storage of specimens. Similar to their participation rates, non-Hispanic black women were least likely to agree to specimen storage than Hispanic and non-Hispanic white women. Age was not associated with specimen storage agreement. Since congenital CMV infection disproportionately impacts black infants it will be critical to develop approaches that educate black women on the importance of congenital CMV infection and newborn CMV screening. Overall, however, the vast majority of women (> 90%) approached agreed to participate in our study indicating that if a newborn CMV screening program were to be implemented, acceptability would most likely be widespread.

Karen B. Fowler (Point of Contact,Primary Presenter,Author), kfowler@uab.edu;
Dr. Fowler is a Professor in the Division of Infectious Diseases in the Department of Pediatrics and the Co-Director of the NIDCD CHIMES Study.

ASHA DISCLOSURE:

Financial - Receives Grants for Employment from NIH grant to UAB.  

Nonfinancial - No relevant nonfinancial relationship exist.

Emily Mixon (Author), emixon@uab.edu;
Ms. Mixon is a Clinical Data Manager in the Division of Infectious Diseases in the Department of Pediatrics and is the Data Manager for the NIDCD CHIMES Study

Alice E. Brumbach (Author), abrumbach@peds.uab.edu;
Ms. Brumbach is a Nurse Coordinator in the Division of Infectious Diseases in the Department of Pediatrics and is the nurse coordinator for the Central Site of the NIDCD CHIMES Study.

Mirjam C. Kempf (Author), mkempf@uab.edu;
Dr. Kempf is an Associate Professor in the School of Nursing and a Co-Investigator for the NIDCD CHIMES Study.

Shannon A. Ross (Author), sross@peds.uab.edu;
Dr. Ross is an Associate Professor in the Division of Infectious Diseases, in the Department of Pediatrics and a Co-Investigator for the NIDCD CHIMES Study.

Suresh Boppana (Co-Presenter), sboppana@peds.uab.edu;
Dr. Boppana is a Professor in the Division of Infectious Diseases in the Department of Pediatrics and the PI of the NIDCD CHIMES Study.

ASHA DISCLOSURE:

Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

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