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9/26/2014  |   4:30 PM - 6:00 PM   |  

Associations between antibodies against the endothelial cell and Cytomegalovirus in serum of children with cochlear implant surgery

Abstract: Background: Cytomegalovirus (CMV) is the common causes of SNHL (Sensorineural hearing loss) in Iranian children. Immune-mediated vascular damage induced by endothelial cell antibodies may have a prominent role in sensorineural hearing loss. OBJECTIVES: To determine the relation between serum CMV antibodies and AECA in children with cochlear implant surgery. Materials & methods: A cross sectional study was performed on 76 cases with severe SNHL at cochlear implant ward in our center.The titers of antibodies against endothelial cell (IFA)and CMV IgG & IgM (ELISA) determined in cases. RESULTS: Positive AECAs:14.4 % (11/76) of cases ; Positive CMV-IgM &IgG were determined in %52;34.6% ; A meaningful correlation was observed between positive AECAs and CMV infections . Conclusion: At least in our country, in younger application of specific anti CMV drugs are preferred. Immunosuppressive therapy is only recommended in older cases with positive AECAs.

Samileh Noorbakhsh (Primary Presenter), samileh_noorbakhsh@yahoo.com;
Professor of Ped Infec Diseas in IUMS;'Research center of ped infec disease in Rasoul , Iran University of medical sciences, Tehran, Iran fror 28 years .

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