September 26-27, 2014
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Abstract Details9/27/2014 | 9:30 AM - 10:00 AM | Topical Session 4 | Ballroom A Consequences and Risk factors Of congenital CytomegalovirUS (CROCUS) study - disease burden of congenital CMV infection in the Netherlands. Introduction: Primary or recurrent cytomegalovirus (CMV) infections during pregnancy can lead to congenital CVM infection (cCMV) and subsequent long-term sequelae (including hearing loss and psychomotor impairment) in the child. Aims: The CROCUS-study aims to describe the burden of disease of cCMV in children at 5 to 6 years of age in the Netherlands. In addition, possible predictors for long-term sequelae will be investigated. These data are necessary to discuss the need for and evaluate benefits and disadvantages of future preventive measures such as neonatal screening or vaccination. Methods: We asked 73,000 parents in the Netherlands for informed consent for testing their child’s dried blood spot for cCMV. All parents of children with a cCMV were notified and asked to participate in the second part of this study. For these children and a matched CMV negative control group data will be collected on hearing, development and quality of life through various health care providers and parent questionnaires. Results: Over 31,000 samples were tested on cCMV and 156 children with a cCMV were found. This indicates a birth prevalence of 0.49% (95% CI: 0.41-0.57), which is in accordance with previous findings. Of these 156 children, only four parents knew that their child had cCMV. A short medical history revealed that at least six children had symptoms possibly related to cCMV in whom the diagnosis had not been considered previously. Conclusion: - This study provides relevant information about the disease burden of cCMV for future policy making concerning neonatal screening program for cCMV in the Netherlands. - Under-diagnosis of cCMV occurs. Improved awareness of CMV-infection in the Netherlands is needed.
Marjolein Korndewal (Point of Contact,Primary Presenter,Author), marjolein.korndewal@rivm.nl;
ASHA DISCLOSURE:
Jeroen Cremer (Author), jeroen.cremer@rivm.nl;
Rob van Binnendijk (Author), rob.van.binnendijk@rivm.nl;
Anne Marie Oudesluys - Murphy (Author), h.m.oudesluys-murphy@lumc.nl;
Aloys Kroes (Author), a.c.m.kroes@lumc.nl;
Marianne van der Sande (Author), marianne.van.der.sande@rivm.nl;
Ann Vossen (Author), a.c.t.m.vossen@lumc.nl;
Hester de Melker (Author), hester.de.melker@rivm.nl;
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