September 26-27, 2014
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Abstract Details9/26/2014 | 11:15 AM - 11:45 AM | Ballroom A Impaired balance and neurodevelopmental disabilities among children with congenital cytomegalovirus infection Introduction: In addition to the risk of acquired hearing impairment, congenital CMV infection is also a risk factor for other neuro¬logical disabilities such as epilepsy, cognitive deficits and motor deficits, including cerebral palsy. Visual impairment occurs after congenital CMV infection but is seldom reported. Autism spectrum disorders and attention deficit hyperactivity disorder have been reported by only a few authors. Speech and language disorders as well as balance im¬pairment have also been reported as sequele of CMV. No studies however have thoroughly evaluated the characteristics of vestibular end-organ dysfunction which leads to the balance disturbance in the setting of congenital CMV related hearing impairment. Identi¬fication of comorbid conditions is of utmost importance, as children with associated difficul¬ties and disabilities need more support in daily life than children that have hearing impairment alone. Aim: The aim of this study was to evaluate disabilities in a well-defined group of children with congenital cytomegalovirus (CMV) infection and severe hearing impairment, treated with cochlear implants. Methods: A case-control study where 26 children with congenital CMV infection were assessed by a multidisciplinary team for balance difficulties, neurodevelopmental disabilities and for language and visual impairment. As controls served 13 children with severe hearing impairment due to connexin 26 mutations. Results: The children with congenital CMV infection had significantly higher frequency of balance disturbances (88%) compared to the control group, in which no children showed such disturbances. Moreover, neurodevelop¬mental disabilities and feeding difficulties were frequent among the children with congenital CMV infection. Conclusion: Congenital CMV infection affects the general development of the brain and gives rise to a complex pattern of difficulties. In children with hearing impairment and/or balance disturbance and/or neurodevelop¬mental disabilities, congenital CMV infection needs to be considered.
Eva Karltorp (Point of Contact,Primary Presenter), eva.karltorp@karolinska.se;
ASHA DISCLOSURE:
Katarina Hedman Lindström (Author), katarina.hedman-lindstrom@karolinska.se;
Ilona Lewensohn-Fuchs (Author), ilona.lewensohn-fuchs@karolinska.se;
Kristina Teär Fahnehjelm (Author), kristina.tear-fahnehjelm@ki.se;
Mimmi Eriksson Westblad (Author), mimmi.eriksson-westblad@karolinska.se;
Ulrika Löfkvist (Author), ulrika.lofkvist@karolinska.se;
Luca Verrecchia (Author), luca.verrecchia@karolinska.se;
Mona-Lisa Engman (Author), mona-lisa.engman@karolinska.se;
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