Abstract Details
10/09/2023 | 3:00 PM - 3:25 PM | 6619
Neurodevelopmental outcomes in children with congenital CMV: Results of a systematic review
Abstract Summary
Background: With the emergence of newborn congenital cytomegalovirus (cCMV) screening programs, more infants are being diagnosed and require long term care and support. This follow-up includes anticipatory guidance and therapies to promote development and mediate developmental sequelae of the infection. Objectives: To summarize the literature to date on neurodevelopmental outcomes in children with cCMV with attention to study-specific definitions of disease severity (symptomatic vs. asymptomatic). Methods: This systematic scoping review included studies of children with cCMV ( ? 18 years-old) measuring neurodevelopment in ? 1 domain: global, gross motor, fine motor, speech/language, and intellectual/cognitive. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. PubMed, PsychInfo and Embase databases were searched. Results: 33 studies met inclusion criteria and were included in the review. Global development most frequently measured neurodevelopmental outcomes (n=21), followed by intellectual/cognitive (n=16) and speech/language (n=8). Most (31/33) studies differentiated children by cCMV severity (symptomatic vs. asymptomatic), definitions of which ranged broadly. 15/21 studies described global developmental outcomes categorically (e.g., normal vs. abnormal). Across studies and domains, children with cCMV generally had equivalent or lower scores (vs. controls or normed measures). Conclusions: Variation in definitions of cCMV severity and blunt categorical outcomes may limit the generalizability of findings. Future studies should utilize standardized definitions of disease severity and in-depth measurement and reporting of neurodevelopmental outcomes in children with cCMV.
Learning Objectives
- To recognize the importance of understanding and predicting neurodevelopmental outcomes in children with cCMV
- To summarize the literature to date on neurodevelopmental outcomes in children with cCMV
- To examine limitations in the present literature and biases
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Presenters
Clare Lauer | Co-Author
cslauer@umich.edu;
Clare Lauer is currently completing a Post-MSW Fellowship with the University Center for the Child and Family through the Mary A Rackham Institute at the University of Michigan. Previously, she worked as a Research Technician Associate focused on congenital CMV research through Michigan Medicine. Clare completed her Master of Social Work degree in Interpersonal Practice in Integrated Health, Mental Health & Substance Abuse through the University of Michigan School of Social Work in the spring of 2022.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Jason Weinberg | Co-Author
jbwein@umich.edu;
Dr. Weinberg obtained his A.B. in Psychology from Princeton University and his M.D. at Duke University. He completed a residency in Pediatrics and served as Chief Resident at the Children’s Hospital/ University of Colorado Health Sciences Center in Denver Colorado. He then completed a fellowship in Pediatric Infectious Diseases at the University of Michigan. He is active in patient care and basic science research, and he teaches graduate students, medical students, residents in Pediatrics, and fellows in Pediatric Infectious Diseases. The Weinberg Laboratory is focused on understanding interactions between viruses and host immune responses. The overarching goal of our work is to define ways in which specific components of the immune system contribute to appropriate control of viral replication but also induce inflammation that contributes to tissue damage and disease.
ASHA DISCLOSURE
Financial - No relevant financial relationship exists.
Nonfinancial - No relevant nonfinancial relationship exists.
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Megan Pesch | Primary Presenter, Author
pesch@med.umich.edu;
Dr. Pesch is a Developmental and Behavioral Pediatrician and researcher at the University of Michigan where she is the Director of the Congenital CMV Developmental Follow-up Clinic. She serves as the President of the National CMV Foundation. Her research interests include the early screening and diagnosis of congenital CMV, as well as the behavioral and developmental outcomes of children with congenital CMV. She is also a proud mother of a daughter with cCMV.
ASHA DISCLOSURE
Financial - Receives Consulting fee for Consulting from DiaSorin Molecular. Receives Consulting fee for Consulting from MedScape. Receives Salary for Employment from University Of Michigan.
Nonfinancial - Has a Personal (Serve on Board of Directors) relationship for Board membership.
AAA DISCLOSURE
Financial - Receives support from University of Michigan (all authors employed by) Pesch - speaker honoraria for diasorin, consultant for medscape/webmd Pesch and weinberg - NIH funding Pesch - Gerber foundation funding for Pesch - speaker honoraria for diasorin, consultant for medscape/webmd Pesch and weinberg - NIH funding Pesch - Gerber foundation funding.