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A Retrospective Study of Congenital Cytomegalovirus (cCMV) Infection Among Newborns in the Neonatal Intensive Care Unit at UAB Hospital
Abstract Summary
Background: The University of Alabama at Birmingham Regional Neonatal Intensive care unit (UAB RNICU) has undertaken universal neonatal screening for congenital cytomegalovirus (cCMV) since the 1980s. The UAB RNICU is a 120-bed level IV NICU, the only Level IV NICU in Alabama. Objective: To determine the cCMV prevalence rates and identify key epidemiologic factors associated with higher rates of cCMV in the UAB RNICU. Methods: Between 2011 and 2019, approximately 10,888 infants were tested for cCMV by either urine or saliva rapid culture. An additional 5,000 infants are expected to be tested for cCMV in the UAB RNICU between 2020 and 2023. We are completing an electronic medical record (EMR) chart review from 2011 to 2023, evaluating demographics, zip codes, related pregnancy and delivery complications, newborn outcomes, and tests and procedures performed while the infant was hospitalized to identify factors associated with a higher risk of cCMV. Additionally, we will compare data from before and during the COVID-19 pandemic to assess epidemiologic changes related to the pandemic. Results: The UAB RNICU cohort is 80% inborn. Race/ethnicity is 45% Non-Hispanic Black, 41% Non-Hispanic White, 8% Hispanic White, 1% Asian, and 5% Unknown. Between 2011 and 2019, 66 infants screened positive for CMV. The cCMV infection rate was 6.1 per 1000 live births (95% CI, 4.7 - 7.7 per 1000). Conclusions: In the UAB RNICU, the prevalence of cCMV infection was slightly higher than previously reported cCMV rates for the United States. Characterizing populations with a higher risk for cCMV infection will better direct prenatal discussion of cCMV exposures and screening.
Learning Objectives
- Identify maternal factors associated with higher rates of congenital cytomegalovirus in the Birmingham, Alabama area.
- Differentiate rates of congenital cytomegalovirus infection and maternal factors prior to and during the COVID-19 pandemic.
- Characterize populations with a higher risk for congenital cytomegalovirus infection to better direct prenatal discussion of exposure and screening.
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Presenters
Kylee Miller | Primary Presenter, Author
kyleemiller@uabmc.edu;
Dr. Kylee Miller is a second year Neonatal-Perinatal Fellow at the University of Alabama at Birmingham (UAB). Her fellowship research projects are focused on cytomegalovirus transmission and epidemiology in the Birmingham, Alabama area.
ASHA DISCLOSURE
Financial - No relevant financial relationship exists.
Nonfinancial - No relevant nonfinancial relationship exists.
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Karen B. Fowler | Author
kfowler@uab.edu;
Dr. Fowler is a Professor in the Division of Infectious Diseases in the Department of Pediatrics at the University of Alabama at Birmingham.
ASHA DISCLOSURE
Financial - Receives Honoraria excluding diversified mutual funds for Teaching and speaking from Medscape. Receives Consulting fee for Consulting from Moderna.
Nonfinancial - No relevant nonfinancial relationship exists.
AAA DISCLOSURE
Financial - Receives support from Moderna Medscape for financial.
Nitin Arora | Author
narora;
Dr. Arora is an Assistant Professor in Neonatology at University of Alabama at Birmingham with a research interest in children with congenital CMV infection.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.