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Participation in postpartum cCMV screening research: Racial, ethnic, age, and language disparities

Abstract Summary

cCMV is a population health-based problem that disproportionately impacts Black and multiracial infants (9.5 and 7.8 per 1000 live births, respectively) compared to infants that are non-Hispanic White, Hispanic and Asian (1.0-3.0 per 1,000 live births). Unfortunately, non-White populations are underrepresented in biomedical research in the US. Researchers in Minnesota led a large universal screening study on cCMV detection methods, with data collection from 2016-2022 across five hospitals. At two of the postpartum hospital sites, 10,879 total patients were approached for cCMV newborn screening research. We retrospectively examined patient characteristics for a two-year subsample (n = 4,156) where 3,148 enrolled (75.7%) and 1,008 (24.3%) declined. We compared maternal characteristics including age, race/ethnicity, preferred language, interpreter need, insurance type, and their number of living children. Additionally, we examined whether the time a patient was approached (pre/post COVID-19 pandemic) influenced enrollment decision. Given there is a higher incidence of cCMV in Black and multiracial populations and a low awareness of cCMV in general, it is important to understand the characteristics of individuals who are more and less likely to participate in cCMV research. This could identify populations that researchers should engage to improve cCMV detection in communities with the highest prevalence. Additionally, these findings could inform future research the includes newborn populations.

Learning Objectives

• Describe maternal characteristics of those approached for cCMV screening for biomedical research.
• Assess if maternal characteristics differ by enrollment status.
• Discuss implications of findings for newborn research.

Presentation

3440589_16100WhitneyWunderlich.pdf

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