Abstract Details
9/09/2025 | 11:00 AM - 11:30 AM | Breakout 4 | University Hall
Frontal cortex white matter connections are altered and associated with neurodevelopment in infants with asymptomatic congenital cytomegalovirus infection
Abstract Summary
Background: Unlike infants with symptomatic congenital cytomegalovirus (cCMV) infection demonstrating delayed neurodevelopment and imaging abnormalities, asymptomatic cCMV (a-cCMV) infants present with clear imaging studies and no expected risk for neurodevelopment.
Objective: Demonstrate high-resolution diffusion MRI (dMRI) sensitivity to altered white matter integrity in a-cCMV infants and neuropsychology.
Methods: In the prospective study, 15 a-cCMV infants (13.1±1.5 months; 8 females) identified by newborn screening and 26 age-matched healthy infants (13.1±1.4 months; 15 females) underwent dMRI. Diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and tractography assessed tract-specific microstructure and morphology. Neurodevelopment (Mullen) was tested at 12 and 24 months. A two-sample t-test assessed between-group differences. Pearson correlation (r) analysis and linear mixture modeling utilized the whole imaging dataset and assessed dMRI associations with neurodevelopmental testing.
Results: Microstructural and morphological deficits were in corpus callosum forceps minor-CC-FMi, frontal aslant tract-FAT, corticostriatal tract-CStrT, inferior fronto-occipital tract-IFOF, superior longitudinal fasciculus 2-SLF2, and anterior thalamic radiation-aTR in a-cCMV. No differences were observed in neurodevelopmental subtests at 12 and 24 months. Fractional anisotropy correlated with the 12-month visual reception in CC-FMi, FAT, CStrT, IFOF, SLF2, and aTR (-0.46>r>-0.71; p<0.003), and early learning composite in CC-FMi, CStrT and aTR (-0.42>r>-0.49; p<0.007). Orientation dispersion index correlated with the 12-month visual reception (0.41
This presentation has not yet been uploaded.
No handouts have been uploaded.
Learning Objectives
Presentation
Handouts
Presenters
Rene Labounek | Co-Presenter
rlaboune@umn.edu;
Rene Labounek, Ph.D., is a biomedical engineer in the Medical Imaging Lab (MILab) at the University of Minnesota. He has a strong expertise in biomedical and electrical engineering, mathematics, physics, signal and image processing (including deconvolution techniques and transfer function modeling), biosignal acquisition and analysis, medical imaging, medical image analysis, (clinical) neuroimaging (including magnetic resonance imaging – MRI, functional MRI – fMRI, diffusion MRI – dMRI), brain and spinal cord neuroanatomy, electroencephalography (EEG), simultaneous EEG-fMRI, (clinical) neuroscience, functional retina imaging, informatics, technical computing, computer programming, grid computations and administration, hardware and software solutions, univariate and multivariate (bio)statistics.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Amy Paulson | Author, Co-Author
pauls860@umn.edu;
Amy Paulson is a PhD candidate at the University of Minnesota and member of the Medical Imagin Lab led by Dr. Igor Nestrasil.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Bryon Mueller | Co-Author
muell093@umn.edu;
Bryon A. Mueller is an MRI physicist and Associate Professor of Psychiatry working at the Center for Magnetic Resonance Research (CMRR) and collaborating with Dr. Nestrasil's MILab.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Christophe Lenglet | Co-Author
clenglet@umn.edu;
Christophe Lenglet, Ph.D., is an Associate Professor at the CMRR and an expert in diffusion MRI. He collaborates with Dr. Nestrasil's Medical Imaging Lab.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Monica Bondy | Co-Author
bondy023@umn.edu;
Monica Bondy is a lab manager of the Medical Imaging Lab (MILab) led by Dr. Nestrasil.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Lauren Haisley | Co-Author
haisl011@umn.edu;
Dr. Lauren Haisley, Ph.D., is a pediatric neuropsychologist and an Assistant Professor in the Department of Pediatrics, University of Minnesota.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Meghan Swanson | Co-Author
swanson1@umn.edu;
Dr. Meghan Swanson, Ph.D., is an Associate Professor of Pediatrics and Psychology at the Masonic Institute for the Developing Brain.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Jed Elison | Co-Author
jtelison@umn.edu;
Dr. Jed Elison is an Associate Professor in the Department of Pediatrics and Psycholoy, University of Minnesota.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Erin Osterholm | Co-Author
oste0123@umn.edu;
Dr. Osterholm is Medical Director of the Newborn Intensive Care Unit at the University of Minnesota Medical School and a faculty member in the Division of Neonatology. She is interested in the clinical implications of CMV on neurodevelopment in both preterm and term infants.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Mark R. Schleiss | Co-Author
schleiss@umn.edu ;
Dr. Schleiss is a Professor of Pediatrics and holds the American Legion and Auxiliary Endowed Research Chair at the University of Minnesota Medical School. His laboratory is supported by the NIH. He conducts research in small animal models testing vaccine strategies against congenital CMV infection. His laboratory is also engaged in the study of the epidemiology, pathogenesis and management of congenital and neonatal CMV infections.
ASHA DISCLOSURE
Financial -
Nonfinancial -
AAA DISCLOSURE
Financial - No relevant financial relationship exists.
Igor Nestrasil | Primary Presenter
nestr007@umn.edu;
Igor Nestrasil, M.D., Ph.D., is an Associate Professor of Pediatrics at the University of Minnesota Medical School, Minneapolis, MN, USA.
He is a neurologist by training (Czech Republic), and his lab (Medical Imaging Lab–MILab) focuses on research in quantitative neuroimaging (brain, spinal cord), retinal imaging, and signal processing.
Dr. Nestrasil has conducted brain research on humans and canine and murine mucopolysaccharidosis (MPS) models. In the NIH-funded U54 (Rare Diseases Clinical Research Network (RDCRN) – an initiative of the Office of Rare Diseases Research), he served as a director of the Neuroimaging Core of the Lysosomal Disease Network, LDN). His lab collaborates closely with many faculty members at the Center for Magnetic Resonance Research (CMRR), a world-leading facility in MRI research.
Dr. Nestrasil has received several grants and research funding and participates in clinical studies and trials on neuroimaging in patients with MPS, ALD, and other rare and neurodegenerative disorders.
ASHA DISCLOSURE
Financial - No relevant financial relationship exists.
Nonfinancial - No relevant nonfinancial relationship exists.
AAA DISCLOSURE
Financial - No relevant financial relationship exists.