Abstract Details
8/22/2022 | 2:50 PM - 3:15 PM | Confederation II/III
Viral load as a prognostic indicator of outcomes among children with congenital cytomegalovirus infe
Background: There remains limited data on the role of blood viral load (VL) as a prognostic indicator of congenital CMV infection (cCMV). The objective of this study was to determine the association between baseline VL clinical outcomes among children with cCMV infection. Methods: Retrospective review of all cases of cCMV followed at Centre Hospitalier Universitaire Sainte-Justine (Montreal, Canada) from September 2008 to December 2021 for whom blood VL was measured by quantitative polymerase chain reaction (qPCR) at time of diagnosis (0 - 21 days of life). The association between baseline VL and presenting symptoms (European consensus classification), progressive hearing loss, any neurological sequelae were determined. Results: 84 patients were included in the analysis of whom 62 (74%) were categorized as symptomatic and treated with antivirals. Median VL was significantly higher among symptomatic vs. asymptomatic patients (20 264 copies/ml vs. 2350 copies ml, p <0.01). Among infants with complete hearing assessments, 36/61 (59%) of symptomatic infants had SNHL at baseline; VL was significantly higher among those with SNHL vs. none (25 119 copies vs. 3678 copies, p=0.03). At a median 2.5 years of follow-up (IQR 1.1-4.6
- Determine association between baseline viral load clinical outcomes among children with congenital cytomegalovirus infection
- Determine association between presence of symptoms at baseline and higher viral load
- Predict association between higher viral load and developed neurological sequelae
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Fatima Kakkar (POC-Point of Contact,Primary Presenter), fatima.kakkar@umontreal.ca;
Dr Fatima Kakkar is a pediatric infectious diseases specialist and clinician-researcher in congenital infectious at Sainte-Justine University Health Center in Montreal, Canada, and Associate Professor of Pediatrics at the University of Montreal. Since 2017, she has co-directed the Women and Children’s Infectious Diseases Center “Centre d’infectiologie mère-enfant”, which provides care for infants affected by congenital infections in pregnancy. Her clinical and research
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ASHA DISCLOSURE: Financial - Receives Salary for Protected research time from Fonds de santé recherche quebec. Nonfinancial - No relevant nonfinancial relationship exists. |
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AAA DISCLOSURE: Financial - Receives support from Fonds de recherche santé Quebec (grant support) Altona diagnostics for Fonds de recherche santé Quebec (grant support) Altona diagnostics (equipement, testing kits). |