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8/23/2022  |   2:50 PM - 3:15 PM   |  Governor General III

Confirming congenital CMV: Dealing with diagnostic and management dilemmas when caring for children

Testing of the newborn dried-blood-spot (DBS) is an option for children suspected of having congenital CMV (cCMV) if they present outside the 3-week time window for urine PCR testing. This presentation will utilize patient case review to highlight challenges that occur when relying upon DBS: 1) There are large variations in duration of DBS storage between governments; 2) there are concerns regarding sensitivity of DBS, which increases risk of false negative results, and 3) there can be discrepancy between the results of DBS test and other investigations. The panelists will review options for additional testing, such as brain imaging, when there are difficulties confirming the diagnosis of cCMV. The panelists will also discuss recommendations when it is unclear whether a child’s hearing loss is secondary to cCMV or other diagnosis, such as genetic variants. cCMV screening programs help to remove these potential barriers to diagnosis, but many areas lack access to routine cCMV screening. This panel will provide insight on ways to counsel families on the benefits and limitations of current cCMV testing and how to frame decisions regarding anti-viral treatment and management of hearing loss when there is lack of confirmatory testing.

  • Review options for diagnostic testing for congenital CMV in children who are D/HH
  • Summarize the benefits and limitations of newborn dried-blood spot testing for CMV PCR
  • Describe how confirmatory testing for cCMV may impact hearing and communication management for children who are D/HH

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Patricia Purcell (POC-Point of Contact,Primary Presenter), patricia.purcell@gmail.com;
Patricia L. Purcell, MD, MPH, is an assistant professor and clinical researcher in Pediatric Otolaryngology at the University of Michigan. Her research interests focus on improving rehabilitation outcomes for children who are deaf and hard of hearing, including children with hearing loss associated with congenital cytomegalovirus.

      ASHA DISCLOSURE:

Financial - No relevant financial relationship exists.

Nonfinancial - Has a Patricia L Purcell: National CMV Foundation relationship for Board membership.  


      AAA DISCLOSURE:

Financial - Receives support from Patricia L Purcell: - National CMV Foundation (non-financial) Dylan K. Chan: - Jacaranda Biosciences, Inc (Ownership interest (stocks/stock options/excluding diversified mutual funds)) (Ownership Interest includes stock, stock options, patent or other intellectual property) Sharon L Cushing: - sponsored research agreements, Cochlear Americas - Speaker’s Bureau, Interacoustics - royalties from Plural Publishing (Balance Disorders in the Pediatric Population) - patent#: 7041-0: Systems And Methods For Balance Stabilization for Patricia L Purcell: - National CMV Foundation (non-financial) Dylan K. Chan: - Jacaranda Biosciences, Inc (Ownership interest (stocks/stock options/excluding diversified mutual funds)) (Ownership Interest includes stock, stock options, patent or other intellectual property) Sharon L Cushing: - sponsored research agreements, Cochlear Americas - Speaker’s Bureau, Interacoustics - royalties from Plural Publishing (Balance Disorders in the Pediatric Population) - patent#: 7041-0: Systems And Methods For Balance Stabilization.