Abstract Details

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9/26/2014  |   10:00 AM - 10:30 AM   |  Arizona

Developmental and cognitive outcomes of children with asymptomatic congenital cytomegalovirus infection: Houston Congenital CMV Longitudinal Study

Background: Although asymptomatic congenital cytomegalovirus (AcCMV) infection has been associated with late-onset hearing loss, data on developmental and intellectual disabilities are lacking. Methods: Children with AcCMV identified through newborn screening and uninfected control-children were evaluated for developmental and intellectual disabilities using the Bayley Scales of Infant Development at 1 year of age and Wechsler Intelligence Scale for Children 3rd edition or Wechsler Abbreviated Scale of Intelligence at 6-17 years of age. A subject with a standard score of <85 at 1 year of age was categorized at risk for developmental disability (DD) and at 6-17 years of age as at risk for intellectual disability (ID). Hearing evaluation included auditory brainstem response at <4 years of age, and by behavioral audiometry at 4-18 years. Results: 103 infants with AcCMV and 49 control-infants were followed for a median of 17.1 years (range 0.3-18.9 years). At 1 year of age, 5 (6.1%) of 82 AcCMV and 4 (18.2%) of 22 control children were categorized as at risk for DD. At 13-17 years of age, 3 (4.1%) of 73 AcCMV children were categorized as at risk for ID. No statistically significant differences in IQ scores were noted when comparing AcCMV and control-children at 6-12 or 13-17 years of age. None of the 9 AcCMV children with HL (2 bilateral, 7 unilateral) among the 72 evaluated at 13-17 years of age were categorized as at risk for ID. Conclusion: Based on this limited sample, infants with AcCMV do not appear to be at greater risk for severe developmental or intellectual disability than uninfected infants. In order to provide guidance to clinicians and parents on prognosis and management of children identified with AcCMV through newborn screening or routine clinical management, more data on the long term cognitive outcomes of infants with AcCMV is needed.

Stephanie Bialek (Point of Contact,Primary Presenter,Author), zqg7@cdc.gov;
Stephanie Bialek is the lead epidemiologist for the Herpes Virus Team in the Division of Viral Diseases in the National Center for Immunization and Respiratory Diseases at the Center for Disease Control and Prevention.

ASHA DISCLOSURE:

Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

Adriana S. Lopez (Author), ail7@cdc.gov;
Adriana S. Lopez is an epidemiologist in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention

Tatiana Lanzieri (Point of Contact,Author), uyk4@cdc.gov;
Tatiana Lanzieri is an epidemiologist in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention.

Angelika Claussen (Author), bhv6@cdc.gov;
Angelika Claussen is a research psychologist in the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention.

Glen Abedi (Author), huv3@cdc.gov;
Glen Abedi is an epidemiologist in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention

Sherry V Sellers (Author), ssellers@bcm.tcm.edu;
Dr. Sellers is Assistant Professor of Pediatrics in the Section of Developmental Pediatrics at Baylor College of Medicine in Houston, Texas.

Marie Turcich (Author), mturcich@bcm.tcm.edu;
Dr. Turcich is a Psychologist in the Section of Developmental Pediatrics at Baylor College of Medicine in Houston, Texas.

Isabella Iovino (Author), iiovino@bcm.tcm.edu;
Dr. Iovino is Assistant Professor of Pediatrics in the Section of Developmental Pediatrics, Baylor College of Medicine in Houston, Texas.

Robert Voigt (Author), rvoigt@bcm.tcm.edu;
Dr. Voigt is Professor of Pediatrics at Baylor College of Medicine and director of the Texas Children’s Hospital Autism Center and the Meyer Center for Developmental Pediatrics.

Chantal Caviness (Author), accavine@texaschildrens.org;
Associate Professor Pediatrics at Baylor College of Medicine; CMV Study co investigator

W Daniel Williamson (Author), dannywilliamsonmd@gmail.com;
W. Daniel Williamson, M.D., is a developmental pediatrician and professor of pediatrics at Dan L. Duncan Children’s Neurodevelopmental Clinic, Children’s Learning Institute in the Division of Developmental Pediatrics at UTHSC-H. Dr. Williamson was Head of the Section of Developmental Pediatrics in the Department of Pediatrics at Baylor College of Medicine, Chief of the Developmental Pediatric Service at Texas Children’s Hospital, and Director of the Meyer Center for Developmental Pediatrics at Baylor College of Medicine and Texas Children’s Hospital.

Gail Demmler-Harrison (Author), gdemmler@bcm.edu;
Professor of Pediatrics at Baylor College of Medicine with over 30 years experience in the research and clinical management of infants with congenital CMV infection; PI of the HOuston Longitudinal Congenital CMV Followup Study; co author or author of numerous publicaitons, chapters and presenter at national and international meetings

Presentation:
310StephanieBialek.pdf

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