September 26-27, 2014
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Abstract Details9/26/2014 | 9:30 AM - 10:00 AM | Topical Session 1 | Idaho Cytomegalovirus infections in the Netherlands - seroprevalence, risk factors and implications. Introduction: Cytomegalovirus (CMV) infections are common worldwide. These infections rarely cause complaints in healthy individuals, but may cause severe disease in immunocompromised individuals. Vertical transmission of CMV during pregnancy can lead to congenital CMV infection and subsequent long-term sequelae in the child. Population based seroprevalence studies are scarce. This study describes the seroprevalence and risk factors for cytomegalovirus in the Netherlands, based on a national serosurvey. Methods: A nationwide serosurveillance study was performed in the Netherlands in 2006-2007. From the participating individuals blood samples and questionnaires were obtained. The sera were tested for IgG-antibodies for CMV using ELISA (ETI-CYTOK-G plus, DiaSorin, Saluggia, Italy). Results: The overall seroprevalence for CMV among the study population (n= 6386) was 45.6% (95%CI: 41.9-49.3%). Individuals of non-Western origin had a higher seroprevalence (77.1%) compared to native Dutch individuals (40.2%) or individuals of Western origin (56.9%). The seroprevalence increased with age and was higher among individuals with lower socio-economic status. Among Native Dutch and Western individuals, women had higher seroprevalence then men. The geometric mean concentrations, among the seropositive individuals, also increased with age and were higher in women compared to men. In women of reproductive age (20-45 year), the seroprevalence of native Dutch or Western women (36.9%) was lower compared to the seroprevalence of non-Western women (85.1%). Conclusion: The difference in seroprevalence between individuals of native Dutch or Western origin and non-Western origin exists both in the general population and in women of reproductive age. The majority of native Dutch or Western women are at risk of primary maternal infection, whereas most of the non-Western women are at risk of recurrent maternal infections. This finding has implications for potential preventive measures for congenital CMV infection; we need to be aware of this difference in case of future vaccination strategies against CMV and neonatal screening programs.
Marjolein Korndewal (Point of Contact,Primary Presenter,Author), marjolein.korndewal@rivm.nl;
ASHA DISCLOSURE:
Fiona van der Klis (Author), fiona.van.der.klis@rivm.nl;
Anne Marie Oudesluys - Murphy (Author), h.m.oudesluys-murphy@lumc.nl;
Aloys Kroes (Author), a.c.m.kroes@lumc.nl;
Marianne van der Sande (Author), marianne.van.der.sande@rivm.nl;
Ann Vossen (Author), a.c.t.m.vossen@lumc.nl;
Hester de Melker (Author), hester.de.melker@rivm.nl;
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