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8/23/2022  |   2:50 PM - 3:15 PM   |  Confederation II/III

Fetal ultrasound signs in congenital cytomegalovirus infection: a systematic review.

To describe fetal ultrasound signs reported in congenital CMV infection, their respective incidence by trimester, and their association with postnatal outcomes. Method: In this systematic review, we searched the following electronic databases: Medline, Ovid, Pubmed, EBM Reviews and Embase. A combination of medical subject headings (MeSH) and terms related to pregnancy, fetal ultrasound and CMV infection were used for the search. Studies in English or French were included, without restriction related to study design. Study selection and data collection were performed by 2 independent reviewers. Results: We included 180 studies. The reported ultrasound signs were ventriculomegaly, microcephaly, intracranial calcification, intrahepatic calcification, hepatomegaly, hyperechogenic bowel, hydrops, ascites, pleural and pericardial effusion, polyhydramnios, oligohydramnios, intrauterine growth restriction and other cerebral and non-cerebral anomalies. After excluding case series, 29 studies were included in the meta-analysis. The incidence of the main fetal ultrasound signs were: hyperechogenic bowel 11.4% [95%CI 6.7 to 18.9], ventriculomegaly 11.4% [95%CI, 7.1 to 17.6], IUGR 9.7% [95%CI 5.1 to 17.7], and microcephaly 8.6% [95%CI 6.7 to 1

  • To learn the principal fetal ultrasound signs observed in congenital CMV infection
  • To observe the respective incidence of each fetal ultrasound sign by trimester
  • To demonstrate their association with postnatal outcomes

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Session Evaluation

Isabelle Boucoiran (POC-Point of Contact,Primary Presenter), isabelle.boucoiran@umontreal.ca;
Isabelle Boucoiran is a maternofetal medicine and reproductive infectious disease specialist as well as a clinician scientist.


Financial - No relevant financial relationship exists.

Nonfinancial - No relevant nonfinancial relationship exists.


Financial - No relevant financial relationship exists.