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8/23/2022  |   2:15 PM - 2:40 PM   |  Confederation II/III

Cranial Ultrasound (cUS) Comparisons in Asymptomatic and Symptomatic Infants Identified in a Univers

Background: With implementation of universal cCMV screening planned for 2023 in Minnesota (MN), it is imperative to define the optimal diagnostic approach for disease classification of identified cases. Cranial ultrasound (cUS) is typically recommended for evaluation of cCMV symptomatology. Method: Newborns were screened for cCMV at six MN nurseries by PCR of dried blood spots (DBS) and saliva. Screen-positive infants had confirmatory urine PCR by day of life 21 and a diagnostic evaluation. Results: Of 19,917 screened newborns, 76 had confirmed cCMV. 60 were asymptomatic (2 with delayed SNHL), 3 were asymptomatic with isolated SNHL at birth, 8 had mild symptoms, and 5 moderate-to-severe symptomatic disease (2 with SNHL at birth and 2 with delayed SNHL). Cranial US exams were available for 68 infants. In infants with any clinical cCMV manifestation, 12 of 17 had at least one abnormal cUS finding, versus 6 of 51 asymptomatic infants (p<0.0001, Fischer’s exact). Four infants with cUS abnormalities defined cases as symptomatic cCMV (DOI: 10.1016/S1473-3099(17)30143-3). Conclusion: The spectrum of cUS findings that define cCMV as “symptomatic” requires clarification. Nonspecific abnormalities are common, even in asymptomatic babies.

  • Determine clinical manifestations of cCMV in infants identified in the context of a universal screening study.
  • Characterize cranial US findings observed during diagnostic evaluation of confirmed cCMV cases.
  • Examine relationship between viral load in saliva samples with clinical findings.

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Session Evaluation

Rebecca Kruc (POC-Point of Contact,Primary Presenter), krucx003@umn.edu;
I am a medical student at the University of Minnesota Medical School. I have been working in the laboratory of Dr. Mark Schleiss for the past 2.5 years, studying congenital cytomegalovirus. I have a background in public health, and hold my MPH degree. I previously worked in enteric infectious diseases at the Minnesota Department of Health. I also previously worked for the Centers for Disease Control in New York City doing tuberculosis control and prevention, as well as in Arizona doing public health emergency preparedness.


Financial - No relevant financial relationship exists.

Nonfinancial - No relevant nonfinancial relationship exists.


Financial - No relevant financial relationship exists.