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9/26/2014  |   4:30 PM - 6:00 PM   |  

Long-Term Growth in Children with Congenital Cytomegalovirus Infection

Title: Long-Term Growth in Children with Congenital Cytomegalovirus Infection Authors: Miller JA, PhD(3), Demmler-Harrison G, MD(1,2), Caviness AC, MD PhD MPH(1,2), Greisser C, RN(1,2), Means A, RD(1), Lanzieri T MD MPH(3), Bialek S, MD MPH(3), Flores M, MS(1,2), and The Houston Congenital CMV Longitudinal Study Group. Author Affiliations: 1 Texas Children’s Hospital, Houston,TX; 2 Baylor College of Medicine, Houston,TX; 3 Centers for Disease Control and Prevention, Atlanta,GA. Background: Abnormalities of growth may be evident at birth and early infancy in congenital CMV infection (cCMV). However, little is known about long-term growth in cCMV. Methods: A longitudinal cohort of congenitally CMV-infected children (symptomatic[ScCMV] and asymptomatic[AcCMV] at birth) and controls (CMV uninfected at birth from same geographical population) was followed from birth to young adulthood and evaluated at intervals for head circumference, weight and length and compared in relation to reference populations developed by WHO (birth to 24 months) or CDC (after 24 months), with growth abnormalities (underweight, underlength or microcephaly) defined as below the 10th percentile. Results: The general ranking of growth metrics was ScCMV < AcCMV < Controls. By age one, microcephaly was present in 66%*, 20%* and 3% of ScCMV, AcCMV and Controls, respectively. Microcephaly persisted in ScCMV: at the last evaluation before age six-and-a-half, 39%*, 1%*, and 0%, respectively, were microcephalic. By age six years, ever-underweight had occurred in 83%*, 32%* and 9%; similarly, ever-underlength occurred in 73%*, 35%*, and 7%, respectively. By last followup (mean age 11.8, 17.2, and 16.9 years), ever-underweight had occurred in 84%*, 39%*, and 16%; with ever-underlength in 79%*, 37%* and 9%, ScCMV, AcCMV, Controls, respectively. 33%* ScCMV were underweight at age 14-18, versus 6% AcCMV and 2% Controls.

Jerry Miller (Primary Presenter,Author), jamiller@texaschildrens.org;
Dr. Miller is an epidemiologist with exertise in infectious disease epidemiology, cancer and biostatistics. He has been active in public health and epidemiology research areas including stomach cancer, hepatitis epidemiology, public health emergency preparedness, and outcomes of congenital cytomegalovirus infection. His earlier research showed that the stomach bacterium Helicobacter pylori was directly mutagenic, supporting its classification as a causative agent for stomach cancer. He and colleagues have examined the effectiveness of prevention and control programs for hepatitis and breast cancer in underserved populations. He has also researched the knowledge and training needs of health workers in bioterrorism-related outbreaks. Dr. Miller has contribued to the BBC and ABC news on health matters, taught statistics and global health to nursing students and has authored or co-authored over 10 publications in health and epidemiology. He lives with his wife in Houston, Texas where he enjoys the science of cooking.

ASHA DISCLOSURE:

Financial - Receives Salary for Employment from Centers for Disease Control.  

Nonfinancial - No relevant nonfinancial relationship exist.

Gail Demmler-Harrison (Point of Contact,Co-Presenter,Author), gdemmler@bcm.edu;
Professor of Pediatrics at Baylor College of Medicine with over 30 years experience in the research and clinical management of infants with congenital CMV infection; PI of the HOuston Longitudinal Congenital CMV Followup Study; co author or author of numerous publicaitons, chapters and presenter at national and international meetings

ASHA DISCLOSURE:

Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

Chantal Caviness (Author), accavine@texaschildrens.org;
Associate Professor Pediatrics at Baylor College of Medicine; CMV Study co investigator

Carol Griesser (Author), griesser@bcm.edu;
Carol is a registered nurse and was the research nurse clinical coordinator for the Houston Longitudinal CMV Study- she is now retired.

Ann Means (Author), ameans@texaschildrens.org;
Ann Means is a registered dietician with research experience

Tatiana Lanzieri (Author), uyk4@cdc.gov;
Tatiana Lanzieri is an epidemiologist in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention.

Stephanie Bialek (Author), zqg7@cdc.gov;
Stephanie Bialek is the lead epidemiologist for the Herpes Virus Team in the Division of Viral Diseases in the National Center for Immunization and Respiratory Diseases at the Center for Disease Control and Prevention.

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