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9/26/2014  |   4:30 PM - 6:00 PM   |  

Congenital Cytomegalovirus Infection and Brain Clefting

Background: Human cytomegalovirus (CMV), a major cause of permanent neurodevelopmental disability in children, frequently produces intracranial abnormalities, including calcifications and polymicrogyria, in infants with congenital CMV infections. This report describes the features of cerebral cortical clefting, including schizencephaly, in children with congenital CMV infection. Methods: This is a retrospective review of the medical records of infants and children with congenital CMV infection evaluated at Primary Children’s Medical Center, Salt Lake City, Utah, USA between 1999 and 2008. Findings: Twenty-five children with congenital CMV infection were identified during this ten year period; twenty-three (92%) had computed tomography and seventeen (68%) had magnetic resonance imaging. Imaging was obtained at a median age of 6 months (mode 1 month or less). Of 15 children with confirmed congenital infections, 10 (66%) had polymicrogyria or abnormal gyral patterns, five (33%) had cleft cortical dysplasia, and two (13%) had schizencephaly. Of 10 children with suspected congenital CMV infection, eight (80%) had polymicrogyria, two (20%) had cleft cortical dysplasia, and one (10%) had bilateral schizencephaly with calcifications. Seventeen of the 25 infants (68%) had intracranial calcifications. Interpretation: These results indicate that clefting, either as cleft cortical dysplasia or schizencephaly, is an important feature of congenital CMV infection.

James Bale (Primary Presenter), james.bale@hsc.utah.edu;
Dr. Bale is a Professor of Pediatrics and Neurology. He has served as the Vice Chair for Education in the Department of Pediatrics and was the Director of the Categorical Pediatric Residency Program. He is currently a member of the NST-1 study section of the NIH, a study section that reviews mentored-scientist proposals for the NINDS. He is a nationally recognized expert in the field of pediatric CMV disease.


Financial - No relevant financial relationship exist.

Nonfinancial - No relevant nonfinancial relationship exist.

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