Abstract Details

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9/27/2014  |   9:30 AM - 10:00 AM   |  Topical Session 4   |  Ballroom A

Consequences and Risk factors Of congenital CytomegalovirUS (CROCUS) study - disease burden of congenital CMV infection in the Netherlands.

Introduction: Primary or recurrent cytomegalovirus (CMV) infections during pregnancy can lead to congenital CVM infection (cCMV) and subsequent long-term sequelae (including hearing loss and psychomotor impairment) in the child. Aims: The CROCUS-study aims to describe the burden of disease of cCMV in children at 5 to 6 years of age in the Netherlands. In addition, possible predictors for long-term sequelae will be investigated. These data are necessary to discuss the need for and evaluate benefits and disadvantages of future preventive measures such as neonatal screening or vaccination. Methods: We asked 73,000 parents in the Netherlands for informed consent for testing their child’s dried blood spot for cCMV. All parents of children with a cCMV were notified and asked to participate in the second part of this study. For these children and a matched CMV negative control group data will be collected on hearing, development and quality of life through various health care providers and parent questionnaires. Results: Over 31,000 samples were tested on cCMV and 156 children with a cCMV were found. This indicates a birth prevalence of 0.49% (95% CI: 0.41-0.57), which is in accordance with previous findings. Of these 156 children, only four parents knew that their child had cCMV. A short medical history revealed that at least six children had symptoms possibly related to cCMV in whom the diagnosis had not been considered previously. Conclusion: - This study provides relevant information about the disease burden of cCMV for future policy making concerning neonatal screening program for cCMV in the Netherlands. - Under-diagnosis of cCMV occurs. Improved awareness of CMV-infection in the Netherlands is needed.

Marjolein Korndewal (Point of Contact,Primary Presenter,Author), marjolein.korndewal@rivm.nl;
Marjolein Korndewal is a PhD-student at the National Institute for Public Health and the Environment (RIVM) at the Centre for Infectious Diseases, Epidemiology and Surveillance and the Leiden University Medical Centre (LUMC) at the department for Medical Microbiology. Currently she is involved in her PhD research project on congenital cytomegalovirus infection.


Financial - Receives Salary for Employment from LUMC.   Receives Salary for Employment from RIVM.  

Nonfinancial - No relevant nonfinancial relationship exist.

Jeroen Cremer (Author), jeroen.cremer@rivm.nl;
Jeroen Cremer is a Research Technician at the National Institute for Public Health and the Environment (RIVM) at the Centre for Infectious Disease Research, Diagnostics and Screening. His current research interests include cytomegalovirus, hepatitis B and mumps.

Rob van Binnendijk (Author), rob.van.binnendijk@rivm.nl;
Rob van Binnendijk is Research Scientist in Virology and Immunology at the National Institute of Public Health and The Environment at the Centre for Infectious Disease Research, Diagnostics and Screening. His current research concerns immunity against vaccine preventable diseases and he is laboratory project coordinator for the national surveillance of measles-, mumps-, rubella- and parvo-viruses.

Anne Marie Oudesluys - Murphy (Author), h.m.oudesluys-murphy@lumc.nl;
Anne Marie Oudesluys-Murphy is a professor of Social Paediatrics at the Willem-Alexander Children's Hospital at the Leiden University Medical Center (LUMC). Her fields of interest include Childhood hearing impairment, Breastfeeding, Developmental delay and Child Abuse.

Aloys Kroes (Author), a.c.m.kroes@lumc.nl;
Aloys (“Louis”) Kroes is head of the Department of Medical Microbiology at Leiden University Medical Center (LUMC) and Professor in Clinical Virology. His research interests include Clinical virology, Infections in immunocompromised hosts, Human herpes viruses and Parvovirus B19.

Marianne van der Sande (Author), marianne.van.der.sande@rivm.nl;
Marianne van der Sande is Head of the Centre for Infectious Diseases, Epidemiology and Surveillance at the National Institute for Public Health and the Environment (RIVM). She is Associate Professor at the Julius Center for Health Sciences and Primary Care at the University Medical Centre Utrecht (UMCU).

Ann Vossen (Author), a.c.t.m.vossen@lumc.nl;
Ann Vossen is Medical Microbiologist, Associate professor in Clinical Virology and Principal Investigator on Congenital cytomegalovirus infection at the department of Medical Microbiology, Leiden University Medical Centre (LUMC). Her areas of interest are Clinical Virology, Herpes virus infections in immunocompromised patients, antiviral resistance, Congenital Cytomegalovirus infection and parvovirus B19 infection.

Hester de Melker (Author), hester.de.melker@rivm.nl;
Hester de Melker studied Biomedical Sciences at the University of Leiden and graduated in 1993 with a major in Epidemiology. From 1993 onwards she worked on public health of infectious diseases at the Center of Infectious Diseases Epidemiology at RIVM. Her epidemiological research is mainly directed to vaccine-preventable diseases. She finished her PhD-thesis in 1999. Subsequently in 2000 she was appointed as leader of epidemiological research and surveillance of the NIP (CIE/RIVM and EPI/CIb). She is advisior of the Health Council committee of the NIP since 2005 and participates in in various in European networks. She is (co)author of over 150 peer-reviewed papers mostly in the field of public health. She guides several PhD-projects including a project in close collaboration with Leiden University (Dr. A. Vossen) directed the disease burden on congenital CMV with the aim to study possibilities of primary and secondary prevention measures of congenital CMV.


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