Abstract Details

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9/26/2014  |   9:30 AM - 10:00 AM   |  Topical Session 1   |  Idaho

Cytomegalovirus infections in the Netherlands - seroprevalence, risk factors and implications.

Introduction: Cytomegalovirus (CMV) infections are common worldwide. These infections rarely cause complaints in healthy individuals, but may cause severe disease in immunocompromised individuals. Vertical transmission of CMV during pregnancy can lead to congenital CMV infection and subsequent long-term sequelae in the child. Population based seroprevalence studies are scarce. This study describes the seroprevalence and risk factors for cytomegalovirus in the Netherlands, based on a national serosurvey. Methods: A nationwide serosurveillance study was performed in the Netherlands in 2006-2007. From the participating individuals blood samples and questionnaires were obtained. The sera were tested for IgG-antibodies for CMV using ELISA (ETI-CYTOK-G plus, DiaSorin, Saluggia, Italy). Results: The overall seroprevalence for CMV among the study population (n= 6386) was 45.6% (95%CI: 41.9-49.3%). Individuals of non-Western origin had a higher seroprevalence (77.1%) compared to native Dutch individuals (40.2%) or individuals of Western origin (56.9%). The seroprevalence increased with age and was higher among individuals with lower socio-economic status. Among Native Dutch and Western individuals, women had higher seroprevalence then men. The geometric mean concentrations, among the seropositive individuals, also increased with age and were higher in women compared to men. In women of reproductive age (20-45 year), the seroprevalence of native Dutch or Western women (36.9%) was lower compared to the seroprevalence of non-Western women (85.1%). Conclusion: The difference in seroprevalence between individuals of native Dutch or Western origin and non-Western origin exists both in the general population and in women of reproductive age. The majority of native Dutch or Western women are at risk of primary maternal infection, whereas most of the non-Western women are at risk of recurrent maternal infections. This finding has implications for potential preventive measures for congenital CMV infection; we need to be aware of this difference in case of future vaccination strategies against CMV and neonatal screening programs.

Marjolein Korndewal (Point of Contact,Primary Presenter,Author), marjolein.korndewal@rivm.nl;
Marjolein Korndewal is a PhD-student at the National Institute for Public Health and the Environment (RIVM) at the Centre for Infectious Diseases, Epidemiology and Surveillance and the Leiden University Medical Centre (LUMC) at the department for Medical Microbiology. Currently she is involved in her PhD research project on congenital cytomegalovirus infection.


Financial - Receives Salary for Employment from RIVM.   Receives Salary for Employment from LUMC.  

Nonfinancial - No relevant nonfinancial relationship exist.

Fiona van der Klis (Author), fiona.van.der.klis@rivm.nl;
Fiona van der Klis is head of department Immunesurveillance and Projectleader for RIVM activities in the Caribean islands of the Netherlands at the National Institute of Public Health and The Environment at the Centre for Infectious Disease and Prevention. She is currently involved in laboratory management, supervising vaccine research projects and assay development.

Anne Marie Oudesluys - Murphy (Author), h.m.oudesluys-murphy@lumc.nl;
Anne Marie Oudesluys-Murphy is a professor of Social Paediatrics at the Willem-Alexander Children's Hospital at the Leiden University Medical Center (LUMC). Her fields of interest include Childhood hearing impairment, Breastfeeding, Developmental delay and Child Abuse.

Aloys Kroes (Author), a.c.m.kroes@lumc.nl;
Aloys (“Louis”) Kroes is head of the Department of Medical Microbiology at Leiden University Medical Center (LUMC) and Professor in Clinical Virology. His research interests include Clinical virology, Infections in immunocompromised hosts, Human herpes viruses and Parvovirus B19.

Marianne van der Sande (Author), marianne.van.der.sande@rivm.nl;
Marianne van der Sande is Head of the Centre for Infectious Diseases, Epidemiology and Surveillance at the National Institute for Public Health and the Environment (RIVM). She is Associate Professor at the Julius Center for Health Sciences and Primary Care at the University Medical Centre Utrecht (UMCU).

Ann Vossen (Author), a.c.t.m.vossen@lumc.nl;
Ann Vossen is Medical Microbiologist, Associate professor in Clinical Virology and Principal Investigator on Congenital cytomegalovirus infection at the department of Medical Microbiology, Leiden University Medical Centre (LUMC). Her areas of interest are Clinical Virology, Herpes virus infections in immunocompromised patients, antiviral resistance, Congenital Cytomegalovirus infection and parvovirus B19 infection.

Hester de Melker (Author), hester.de.melker@rivm.nl;
Hester de Melker studied Biomedical Sciences at the University of Leiden and graduated in 1993 with a major in Epidemiology. From 1993 onwards she worked on public health of infectious diseases at the Center of Infectious Diseases Epidemiology at RIVM. Her epidemiological research is mainly directed to vaccine-preventable diseases. She finished her PhD-thesis in 1999. Subsequently in 2000 she was appointed as leader of epidemiological research and surveillance of the NIP (CIE/RIVM and EPI/CIb). She is advisior of the Health Council committee of the NIP since 2005 and participates in in various in European networks. She is (co)author of over 150 peer-reviewed papers mostly in the field of public health. She guides several PhD-projects including a project in close collaboration with Leiden University (Dr. A. Vossen) directed the disease burden on congenital CMV with the aim to study possibilities of primary and secondary prevention measures of congenital CMV.


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